491.

Rubin M, Princiotto JV. Synthetic amino acid chelating agents and iron metabolism. Ann. NY Acad. Sci. 1960; 88:450-459. (CA55:2903f) [Intravenous injections of Fe chelates of ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), or N-(2-hydroxyethyl)-ethylenediaminetetraacetic acid (HOEDTA) into rabbits or rats (1.5-6.0 mg./kg.) gave urinary excretions of 70-92% of the dose. Intraperitoneal and intramuscular injections gave somewhat lower results (50-70%), while oral administration of the chelates had very little effect on the urinary excretion of Fe. A shift from hydrophilic to hydrophobic chelating agents resulted in increased biliary excretion of Fe. EDTA and HOEDTA chelates provided pos. hemoglobin responses in animals with Fe-deficiency anemia.]

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