489.

Rieders F, Brieger H. Edathamil disodium calcium (Na2CaEDTA): Absorption by the oral route - interactions with metals in vivo - diagnostic and therapeutic use. Proc. 7th Annual Mtg. Amer. Acad. Occup. Med. 1955; pp. 83-84. (1607) [Orally administered CaNa2EDTA is apparently not absorbed as such. Its total effect is a transfer of metal from the intestinal to the urinary route of excretion without appreciable removal of metal from the tissues. Experimental evidence supporting this statement is presented. Increases of urinary Pb excretion by 1 parenteral administration of Na2CaEDTA are much greater in Pb poisoning than in other pathologic or normal conditions and hence are of diagnostic significance. In chronic occupational Pb poisoning, intravenous treatment with 1 infusion/wk mobilizes more Pb/infusion than if the drug is given daily. Clinical improvement under such intermittent therapy is as rapid and as lasting as under continuous therapy. The effect of this reagent on excretion of Fe, Cu, and Zn is discussed briefly.]

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