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Osani H, Motomura H, Makihata M. Continuous oral administration of calcium EDTA. Rodo Kagaku. 1964; 40(3):113-120. (CA63:16996e) [Mice were fed dry food and water contg. Ca EDTA and Cd(NO3)2 to study the toxicity of Ca EDTA and the effect of its oral administration on removing Cd from the liver and kidney. Administration of 4% Ca EDTA soln. caused dehydration, diarrhea, and wt. loss, and the mice died in a week; 2% Ca EDTA caused anemia and wt. loss, and the mice died after 50 days; with 1% Ca EDTA the mice survived >150 days and only slight anemia was observed. Nephrotoxic action was not noticed in oral administration. Tissue Cd was not removed by 1% Ca EDTA treatment, but the hematocrit was noticeably diminished in the treated mice.]

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