465.

Naylor GJ. Treatment of pre-menstrual syndrome. U.S. US 4,414,212 (Cl. 424-247; A61K31/54) 08 Nov 1983. Appl. 354,065, 02 Mar 1982; 3 pp. (CA) [Pharmaceutical formulations comprising methylene blue (I) or its bioprecursors, ascorbic acid, glutathione, EDTA or their physicol. acceptable salts or esters are useful for the treatment and(or) prophylaxis of premenstrual syndrome. Tablets, capsules, suppositories, and pessaries contain 25-400 mg I/formulation and 200 mg to 1 g ascorbic acid, glutathione, and EDTA. Thus, premenstrual syndrome (including the wt. change) of a female patient virtually disappeared when she was treated with 150 mg I, twice daily, commencing on the 12th day of her menstrual cycle.]

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