453.

Zipkin I. Caries-potentiating effect of ethylenediaminetetraacetic acid in the rat. Proc. Soc. Exptl. Biol. Med. 1953; 82:80-83. (CA47:4972f) [Addn. of 0.5% of the compd. to a cariogenic diet appeared to promote caries to a marked degree. Concomitantly, the hematocrit value was lowered, and almost complete inhibition of incisor pigmentation was observed. These effects of the compd. do not seem to be assocd. with its ability to decalcify rat molar teeth in vivo. Citrate and Calgon added to a cariogenic diet or to the drinking water did not significantly increase the severity of caries.]

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