451.

Zahorski W, Myslak Z. Use of Ca-EDTA in the organized action against plumbism in industry. XII Internatl. Cong. Occup. Health, Helsinki, Finland. 1957; Vol. III, pp. 242-243. (1881) [As first tested on 60 cases of Pb poisoning, oral doses of 2-3 g EDTA/day in 0.25-g tablets given every 2 hr for a total dose of 20 g gave good results. Since a 2-g oral dose every other day produced an elimination of Pb that was similar or even greater than that obtained by a daily dose, fractions of a total dose of 20 g were subsequently administered every other day over a period of 12-14 days. Counts of stippled erythrocytes, urinary coproporphyrin (CP), and Pb, and blood Pb were used as diagnostic criteria. Having established that the CP elimination by nonexposed subjects given EDT does not exceed 1 mg/24 hr in the 1st 3 days, the mobilization test was used to confirm diagnosis of Pb poisoning. Based on these experiments, a prophylactic program for the nonferrous smelting industry was developed with the active participation of factory physicians. In industries with high exposure, Pb poisoning recurred 2-3 mo after return to work. A 2nd treatment allowed the workers to return to work for a number of months without further signs of Pb absorption. The authors conclude that a greater application and systematic and frequent examination would diminish the number of workers who would be forced to leave these industries.]

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