428.

Viteri FE, Garcia-Ibanez R, Torun B. Sodium iron EDTA as an iron fortification compound in Central America. Am. J Clin. Nutr. 1978; 31(6):961-971. [Studies were performed in 7 children and 98 adults to compare the proportion of Fe absorbed when administered as (Fe2(SO4)3, Na Fe EDTA, and ferrous ascorbate. Studies in children (mostly Fe deficient) showed that when the compds. were given with a milk-rice-sugar formula totalling 5 mg Fe, Fe from Hb was absorbed best, followed by Na Fe EDTA and by Fe2(SO4)3 (mean absorption 34.5, 8.6, and 3.3% resp.). Studies in normal or Fe-deficient adults also demonstrated a better absorption of Fe from Na Fe EDTA than from Fe2(SO4)3 whether these compds. were given in an aq. soln. (5 mg Fe) or with a std. meal consisting of beans, tortillas, bread, and coffee providing also a total of 5 mg Fe. Hb Fe under the same conditions was absorbed in the same proportion to the ref. Fe ascorbate, always being higher than Fe absorbed from the other compds. Fe2(SO4)3 and Na Fe EDTA mixed in the same meal were absorbed in the same proportion as when Na Fe EDTA alone was added to the meal and 2-3 times better than when Fe2(SO4)3 alone was added to the meal. Addn. of desferrioxamine depressed Fe absorption from Fe2(SO4)3 and Na Fe EDTA, the latter being less affected. Addn. of ascorbic acid increased absorption from both. When the compds. were added to the meal to provide 50 mg Fe, percentage absorption was depressed in relation to the smaller Fe dose in the case of Fe2(SO4)3 and Hb but remained unaltered in the case of Na Fe EDTA. Addn. of 45 mg Fe as Fe2(SO4)3 or Na Fe EDTA to 0.4 mg Fe from Hb in the meal did not change Hb Fe absorption. Addn. of 45 mg Fe as Hb or Na Fe EDTA to 0.4 mg Fe from Fe2(SO4)3 in the meal enhanced Fe absorption from the latter in the same proportions. Addn. of 45 mg Fe as Fe2(SO4)3 and Hb to 0.4 mg Fe as Na Fe EDTA in the meal resp. depressed and enhanced Fe absorption from Na Fe EDTA. Na Fe EDTA, Fe2(SO4)3, and nonheme food Fe form a common pool different from the heme pool but which is changed in its characteristics by the presence of Na Fe EDTA, resulting in a better absorption of Fe.]

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