427.

Varela G, Sanchez FS. Pharmacodynamics of sodium versene. I. Toxicity and action on smooth muscle. Arch. inst. farmacol. exptl. 1952; 4:5-11. (CA47:6554b) [Orally, as much as 1 g./kg. body wt. of Na versene (I) given to rats produced no effect. Intravenously, MLD for rats is 51.2 mg./kg. body wt. The contractions of isolated rabbit intestinal, or guinea-pig uterus, muscle, suspended in either Tyrode or Ringer soln., were destroyed by the addn. of 0.1 ml. of 2.4% I. The addn. of I completely represses the effect of adrenaline and of acetylcholine. All the effects observed could be reversed by washing.]

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