413.

Suso FA, Edwards Jr. HM. Ethylenediaminetetraacetic acid and zinc-65 binding by intestinal digesta, intestinal mucosa, and blood plasma. Proc. Soc. Exp. Biol. Med. 1971; 138(1):157-162. (CA76) [In chickens fed for 2 weeks on diet contg. 70 ppm (HO2CCH2)NCH2CH2N(CH2CO2H)2 zinc and 0.125% EDTA (I), and then injected with 65Zn and EDTA-14C elution peaks from gel filtration of intestinal digesta, intestinal mucosa, and blood plasma prepns. appeared together and the ratios of 14C:65Zn radioactivity were 1.10, 1.26, and 1.26, resp., indicating strong binding of the Zn-EDTA complex. After 150 hr of dialysis the intestinal digesta, mucosal sol. fractions, and plasma samples retained 15, 66, and 98% resp., of 65Zn and EDTA-14C. The EDTA-Zn complex was bound to a MUCOSAL PROTEIN OF 14,000-18,000 mol. wt., and to a PLASMA PROTEIN of 65,000-70,000 mol. wt. which had greater affinity for Zn than the mucosal protein.]

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