408.

Skorkowska-Zieleniewska J, Bartnik J, Mentel M. Preliminary studies on the effect of versenates on the organism in the light of views on possibilities of the use of these compounds in the food industry. Przem. spoz. 1969; 23:237-240. (NA40) [In 2 trials groups of female Wistar rats 4 weeks old weighing 52 g, received a diet without or with disodium versenate (Na2EDTA). In the first trial, 3 groups of 4 rats were given none, 25 or 250 mg Na2EDTA per day per rat. In the second trial, 2 groups of 5 or 6 rats were given none or 250 mg Na2EDTA per day per rat. Rats were killed after 2 weeks in trial 1 and after 6 weeks in trial 2. Fe and Cu in liver as well as Hb in blood were estimated. In both trials there was a considerable decrease of Fe and Hb in all groups given Na2EDTA. Liveweight gain in those groups was somewhat less than in the control ones. The smaller amount of Na2EDTA caused an increase in Cu in liver, while the larger one only slightly increased or decreased Cu.
As the limits set by standards range from 70 to 800 mg versenate per kg food product it was thought that a relatively high intake of versenate by people is possible. It was concluded that versenates should be introduced into the food industry with more caution.]

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