388.

Makashev KK, Akhmedova AS. The effect of ethylenediaminetetraacetate (EDTA) and cortisone on the distribution of phosphorus and calcium in organs and tissues and their excretion from the system after lead intoxication. Trudy Instituta Kraevoi Patologii, Akademiya Nauk Kazakhskoi SSR. 1962; 10:190-197. (1009) [Three groups of white rats (250-300 g weight) were used: 16 were given 1 ml/kg of a 2.5% solution of Pb acetate daily for 4-5 mo. The other 2 groups of 16 each were treated as above and received cortisone or CaNa2EDTA. After symptoms of Pb intoxication appeared, the animals were given once 1000 counts/g tissue of 32P and 45Ca and then daily intramuscular injections of 10-25 mg cortisone or oral doses of CaNa2EDTA. Cortisone caused an increase of excreted P while Ca excretion was unaffected, and an increase of accumulation of 32P and 45Ca in the bone tissue. CaNa2EDTAdecreased 32P and 45Ca accumulation in bone tissue and blood and increased their urinary excretion. CaNa2EDTA was more effective than cortisone for excretion of Pb from the system.]

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