376.

Larsen BA, Hawkins WW, Leonard VG, Armstrong JE. The effect of the prolonged intake of ethylenediaminetetraacetate on the utilization of calcium and iron by the rat. Can. J Biochem. and Physiol. 1960; 38:813-817. (CA54:23067b) [The dihydrate of di-Na ethylenediaminetetraacetate (EDTA) was added at levels of 0.3 and 1.5% to the diet of young rats to produce molar ratios EDTA:Ca:Fe of 1:49:08 and 1:9.8:0.16. These diets did not affect the excretion of Ca or its concn. in blood serum or femur. In both cases the concn. of Fe in serum was increased, and in spleen decreased, and with the higher dietary level of EDTA, the concn. of Fe in the liver was decreased. Other animals were given 0.5 or 3.0 mg. of EDT/day intraperitoneally. The only difference from the above was a decrease in the concn. of Fe in the spleen in the animals which received the larger dose. There was no effect in any case on the size of the liver, spleen, or femur, or upon growth. All the measurements were made after 110-112 days. The larger amts. of EDTA which were used were near the max. which the animals would tolerate for a long period.]

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