313.

Eiichi O, Suzuki S, Fukuda R, Shibata K. The excretion and distribution of radioactive zirconium. I. Experiments with mice. Gunma J Med. Sci. 1960; 9:203-211. (CA55:19011i) [To investigate the effect of various agents on the absorption and excretion of Zr??, carrier-free Zr?? oxalate (I) (1 mc./0.1 cc.) was administered subcutaneously, intraperitoneally, or orally to male mice. Heaviest deposition occurred first in the blood; after 12 hrs. it was highest in the bone. Deposition in organs 12 hrs. after subcutaneous injection followed this descending order: kidney, lung, pancreas, liver, spleen. Intraperitoneal injections produced the same result except that the pancreas was highest in I. Nonradioactive ZrOCl2 added as a carrier to I accelerated the excretion of I in a dose of 0.1 g per mc.Zr??, but inhibited excretion of I above 50 g per mc.Zr?? of ZrOCl2. Ca ethylenediaminetetracetate (EDTA), 0.2 cc. of 0.5% soln. given orally, accelerated accumulation of I and reduced deposition. Subcutaneous injection of Na Ca citrate, 0.1 cc. of 6.4% soln., after subcutaneous injection of I significantly increased the excretion of I. Oral administration of MgSO4, 0.1 cc. of 10% soln., increased excretion and decreased deposition of I. Tetracycline, 1-4 mg., significantly promoted the excretion of I. Subcutaneous injection of Na citrate slightly decreased the excretion and enhanced the deposition of I. II. Experiments with rats. Ibid. 212-218. Male rats were injected with 5 mc./0.2 cc. carrier-free I subcutaneously and intraperitoneally. In both cases I accumulation was highest in the blood, followed in descending order by bone, kidney, lung, liver, spleen, and pancreas. Tricarballylic acid, 8.5 millimoles/kg., enhanced the excretion of I , as did 200 millimoles/kg. of CaEDTA, but neither significantly altered the deposition of I. Na Ca citrate, 13 millimoles/kg., mixed 1:2 and 2:1 with tri-Na citrate significantly enhanced excretion and depressed absorption of I. Tetracycline 25-50 mg. per rat promoted excretion and depressed deposition of I.]

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