311.

Dybing O, Sognen E. Effect of sodium fluoride on the toxicity of red squill. Acta Pharmacol. Toxicol. 1960; 16:242-244. (CA55:6700b) [Red squill was given to rats alone or together with various amts. of NaF or tetracemin disodium (disodium salt of ethylenediaminetetraacetic acid (EDTA). Red squill given orally, 500 mg./kg., caused convulsions in 100 and 70% deaths in rats. Red squill, 500 mg./kg., given orally with 50 mg./kg. of NaF did not result in any convulsions or deaths. Use of 10 mg./kg. of NaF reversed the effects of red squill. When both the NaF and squill were given parenterally or when one was given orally and the other parenterally, the toxic effect of the red squill was not reversed. EDTA had the same effect as NaF. It was suggested that the Ca-binding effect of the 2 substances caused a decreased rate of absorption of red squill from the intestinal tract.]

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