256.

Bersin T, Muller A, Schwarz H. Pharmacological action of some inorganic-organic complex compounds. Arch. Biochem. and Biophys. 1957; 69:507-513. (706) [A number of EDTA salts were prepared. CaNa2EDTA, orally administered to growing albino mice, was somewhat better tolerated than Ca2EDTA. However, the author himself took 0.3 g Ca2EDTA/24 hr for 3 mo and tolerated the drug well. Ca2EDTA is used in the prophylaxis of Pb poisoning. The LD50's (g/kg) for albino mice iv were as follows: CaMgEDTA 1.87; MgNa2EDTA 0.124, BiNaEDTA 0.075. Albino mice injected iv with 1.616 CaMgEDTA became unconscious for some hours but recovered completely. Piperazine CaEDTA is used as vermicide. Authors conclude that the pharmacological effect is produced by the entire EDTA molecule.]

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