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Appel MJ, Kuper CF, Wouteren RA (Dept of General Toxicology, TNO Nutrition and Food Research, Zeist, Neth.). 352654b Disposition, accumulation and toxicity of iron fed as iron (II) sulfate or as sodium iron EDTA in rats. Food Chem. Toxicol. 2001; 39(3):261-269. (CA) [A study was performed to provide data on the disposition, accumulation and toxicity of sodium iron EDTA in comparison with iron (II) sulfate in rats on administration via the diet for 31 and 61 days. Clin. signs, body wts., food consumption, food conversion efficiency, hematol., clin. chem. and pathol. of selected organs were used a criteria for disclosing possible harmful effects. Detn. of iron and total iron binding capacity in blood plasma and non-heme iron anal. in liver, spleen and kidneys were used to assess the disposition and accumulation of iron originating from sodium iron EDTA or iron (II) sulfate. It was concluded that, under the conditions of the present study, iron is accumulated from the diet in liver, spleen and kidneys in a dose-dependent manner, and iron derived from FeEDTA is taken up and/or accumulated less efficiently in liver and spleen than iron from FeSO4. Moreover, feeding iron up to 11.5 and 11.2 mg/kg body wt./day, derived from FeSO4 and FeEDTA, resp., did not result in tissue iron excess nor in any other toxicol. significant effects.]

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