179.

Itoh H, Yamaguchi T, Yamasawa S. Inhibition of hematopoietic action of iron by ethylene-diaminetetraacetate (EDTA). Yokohama Med. Bull 13. 1962; 1:9-16. (CA57:7863b) [Totals of between 100 and 250 g. EDTA were administered daily in drinking water to rats fed a condensed diet. Anemia was induced in some of the rats by depletion from the tail or external jugular vein of an amt. of Fe corresponding to 2% body content. EDTA had no effect on the hemoglobin level and on the red blood cell count of normal rats over a 20-day period even when the EDTA concn. was doubled from 0.4% to 0.8%. EDTA also had no deleterious effect on the normal rise in hemoglobin and red blood cell count of the anemic group fed the Fe diet. But when the EDTA concn. was doubled on the 12th day, the rate of recovery dropped. In a 2nd expt., a 1% soln. of EDTA was given to anemic rats prior to the initial feeding of the Fe diet to detn. the effect on recovery from anemia. The rate of red blood cell formation was depressed for the first 8 days and the rate of hemoglobin formation was depressed for the first 16 days. Evidently, EDTA chelates Fe before the metal is absorbed from the alimentary tract.]

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