166.

Davis PS, Deller DJ. Effect of orally administered chelating agents EDTA, DTPA, and fructose on radioiron absorption in man. Australas. Ann. Med. 1967; 16(1):70-74. (CA67) [Radioiron absorption tests were performed on 17 hematologically normal adult volunteers. A dose of 2 mc. of ??Fe, with 5 mg. of Fe as FeSO4, 50 mg. of ascorbic acid, the test substance, and 200 ml. of H2O were given orally after an overnight fast. Each person was studied 4 times over a period of 10 weeks, during which 0:1, 1:1, 10:1, and 50:1 molar ratios of chelating agent, to Fe were administered. The chelating agents used were EDTA, DTPA (diethylenetriaminepentaacetate), and fructose. The testing as randomized, with each subject serving as his own control. Fe absorption was measured in a whole body gamma spectrometer after the unabsorbed radioactivity had been excreted. EDTA and DTPA had no significant effect on Fe absorption when given in a 1:1 molar ratio with respect to Fe, but reduced it when given in a ratio of 10:1 or 50:1. Fructose had no effect in 1:1 or 10:1 ratios, but increased Fe absorption when given in a 50:1 ratio. The results with fructose may have clin. importance in Fe-deficiency anemia and in the development of siderosis in alcoholics.]

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