137.

Basinger MA, Jones MM, Holscher MA, Vaughn WK. Antagonists for acute oral cadmium chloride intoxication. J Toxicol. Environ. Health. 1988; 23(1):77-89. (CA) [The relative efficacy of a no. of chelating agents when acting as antagonists for oral CdCl2 intoxication in mice was studied. The compds. were administered orally after the oral administration of CdCl2 at 1 mmol/kg. Of the compds. examd., several were useful in terms of enhancing survival, but by far the most effective in both enhancing survival and leaving minimal residual levels of Cd in the liver and the kidney was meso-2,3-di-mercptosuccinic acid (DMSA). Several polyamino-carboxylic acids also enhanced survival. The most effective of these in reducing liver and kidney levels of Cd were diethylenetriaminepentaacetic acid, trans-1,2-diaminocyclohexane-N,N,N1,N1-tetraacetic acid, and tri-ethylenetetraminehexaacetic acid. D-Penicillamine promoted survival but also led to kidney Cd levels higher than those found in the controls. Na 2,3-dimercaptopropane-1-sulfonate was as effective in promoting survival as DMSA but left levels of Cd in the kidney and liver that were ~4 times greater than those found with DMSA.]

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