122.

Savicevic M, Petrovic L, Stankovic M, Djordjevic S. Experiences with CaNa2EDTA (mosatil bayer) in chronic Pb exposure. Zentralblatt fur Arbeitsmedizin und Arbeitsschutz. 1959; 9:6-12 (Jan.) (2062) Thirty foundry workers with an exposure time of 5-16 yr (av 9.9 yr), were treated with CaNa2EDTA for 7 days; 11 patients received iv 2.4 g/day, 5 a daily dose of 1.2 g; 7 men were given 1.2 g/day im and 7 others 3 g/day orally; 4 were left without therapy. Hemoglobin and erythrocyte values increased, punctate cells did not change significantly; reticulocytes tended to decrease slightly. Urinary Pb excretion was particularly high during the 1st day in the parenterally treated groups, less so in the orally treated men. Urinary coproporphyrins and urinary and blood Pb concentrations returned to normal during treatment. A decrease in the Pb line on the gums was noticed in all patients and finally disappeared in 26% of the cases, however, more rapidly so in those treated iv. Arthralgies disappeared in 30% and the pallor in 56%; in the control group, however, it did not change. EDTA had no clinically demonstrable toxic effect except possible diarrhea in 5 cases the origin of which was, however, uncertain.

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