118.

Pedinelli M, Stringari M. Observations on the treatment "per os" with chelating agents in tetraethyl lead production workers. Rassegna di Medicina Industriale. 1959; 28:514-525 (Nov.-Dec.) (2048) The principal stages of TEL production and the occupational hazards of each stage are described. EDTA in the form of 0.25 g tablets was given to 10 TEL production workers in daily doses of 1.0-1.5 g for 8-12 consecutive days. All these subject had a urinary Pb concentration of ~200 mg/l. One of the men was successively treated with cysteamine and an 11th man was given only cysteamine treatment. Graphs illustrating the urinary Pb excretion for each man during treatment show that the Pb excretion increases considerably to the 3rd-5th day of treatment with EDTA and returns to low values by the 10-12th day. The increase is largest in workers who had been exposed to metallic Pb in addition to TEL. Similar though less pronounced results were obtained with cysteamine. Both drugs were well tolerated in the doses administered.

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