117.

Nielsen FH, Sunde ML, Hockstra WG. Effect of some dietary synthetic and natural chelating agents on the zinc-deficiency syndrome in the chick. J Nutr. 1966; 89(1):35-42. (CA65:14176h) The objective of these studies was to assess the effects of some synthetic and natural Zn-binding agents on the Zn-deficiency syndrome in chicks fed diets contg. isolated soybean protein. Synthetic chelating agents ethylene-N,N1-diacetic acid (EDDA) (Zn stability const. 11.10), HEDTA (14.50), EDTA (16.50), and DTPA (18.14), at 1.8 millimoles/kg. diet, and natural chelating agent cysteine (18.20), at 0.5% of the diet, alleviated all Zn-deficiency symptoms, which included poor growth, poor feathering, low length-to-width ratios of femurs, low Zn content of tibias, and leg abnormalities. HEIDA (8.57) slightly improved the growth, feather score, and leg score. Supplemental histidine (12.88) at 0.5% of the diet alleviated the bone disorder; however, it did not improve growth or increase the Zn content of bone. CDTA (18.67) substantially depressed growth of Zn-deficient chicks, but the effect was not statistically significant. Synthetic chelating agents DHEG (5.36), ID (7.02) and (ethylenebis(oxyethylenenitrilo))tetraacetic acid (EBONTA) (11.00), and natural chelating agents xanthurenic acid, kyburenic acid and anthranilic acid (20.93), at 1.8 millimoles/kg. diet, and glutamic acid (9.46), cystine, and tryptophan (9.30) at 0.5% of the diet had no effect on the Zn-deficiency syndrome. All chelating agents with stability consts. for Zn between 11.10 and 18.20, except histidine, overcame all Zn-deficiency symptoms, whereas histidine alleviated only bone and, to some extent, feather defects.

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