116.

Vozar L. The action of complexon 3 on the copper balance and level in the organism after oral administration. Pharmazie. 1959; 14:459-466. (CA54:7892d) [Complexon 3 (di-Na salt of ethylenediaminetetraacetic acid) (I) intervenes in Cu metabolism, as shown by short- and long-term administration to rats in doses of 40 mg./100 g./day. In short-term feedings (1-3 days) a pronounced decrease of Cu in liver, kidneys, and skeletal musculature was noted, which was greater with doses of 80 mg. I/100 g. In long-term tests (20-40 days) removal of Cu from liver, kidneys, and heart was accompanied by a deposition of Cu in skeletal muscle and in the gray matter of the cerebral cortex. Rats which received I for 20 days, then none for 20 days, still retained significantly higher Cu content than control animals in various organs except for the spleen. The av. daily balance of Cu was reduced by I through increased Cu excretion in the feces. The relation of the balance of bound Cu to Cu combined to I (and other similar complexes) is discussed.

Gordon Research Institute / Reference Material

Gordon Research Institute    Dr. Garry F. Gordon MD DO MD(H)
600 N Beeline Hwy, Suite B, Payson, AZ 85541
Phone: 928-472-4263    Fax: 928-474-3819
Email Dr.Gordon