110.

Makashev KK. Effect of calcium and disodium salts of ethylenediaminetetraacetic acid on lead absorption, accumulation, and excretion from the system after lead intoxication. Trudy Inst Kraevol Patologil, Akademiya Nauk Kazakhskoi SSR. 1962; 10:180-189. (1008) The preparations used in these experiments were CaNa2EDTA (CaNaE) and Na2H2EDTA (NaHE). White rats (200-300 g weight) were divided into 3 groups to receive the following orally: (1) 18 controls, 210Pb; (2) 10, 210Pb + CaNaE; (3) 10, 210PB + NaHE. All animals were first subjected to Pb intoxication by the administration of 1 ml 2.5% solution of Pb acetate/kg/day for 4-5 mo, until signs of poisoning developed. 210Pb was then administered at 2000 counts/g tissue. Groups 2 and 3, after this administration received by stomach tube 1 ml 10% solutions/kg of CaNaE and NaHE, respectively, over a period of 30 days. The elimination of 210Pb was followed daily in urine and feces and the radioactivity of 10 organs and tissues was measured on days 5, 15 and 30 of the experiment. The results showed that both EDTA salts decreased Pb absorption in the digestive tract, and increased the excretion of Pb, primarily in the feces, but NaHE was approximately twice as effective as CaNaE. The accumulation of 210Pb in organs of rats given NaHE was significantly smaller than in controls, and the latter caused higher accumulation of Pb in bones than CaNaE.

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