109.

Krari N, Allain P. Effects of three chelating agents, EDTA, NTA, and TPP, on the concentration of elements in rat tissues. Biol. Trace Elem. Res. 1991; 29(2):125-131. (CA) [Ethylene diamine tetraacetic acid (EDTA), nitrilotriacetic acid (NTA), and tripolyphosphate (TPP) sodium salts were given orally to rats at a dose of 1 mmol/kg/d for 35 d. The concns. of Na, K, Ca, Mg, P, S, Fe, Sr, Cu, and Zn were detd. in blood, plasma, brain, heart, muscle, liver, kidney, duodenum, and bone of control rats and of the rats receiving EDTA, NTA, and TPP. The main effect induced by EDTA, NTA, and TPP was a decrease in the concns. of several elements (Ca, Mg, Fe, and P) in the duodenum. Otherwise, EDTA induced an increase of Zn in the kidney (+20%), NTA, an increase of Fe in liver (+29%), and particularly an increase of Zn in bone (+44%). TPP induced a slight decrease of Zn and Cu in liver. Thus, EDTA, NTA, and TPP taken orally at a dose of 1 mmol/kg/d for 35 d induced moderate changes in the concns. of some elements in rat tissues, but without signs of toxicity.]

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