105.

Harishima S, Tsuchiya K, Kondo H, Motouchi M, Sakaguchi T, Mori A. Therapy and prevention of lead poisoning with calcium versenate. Keio J. Med. 7. 1958; 93-105. (1914) [When Pb poisoned dogs were treated parenterally with EDTA, plasma Pb increased greatly while the Pb content of liver and kidneys was markedly decreased compared to untreated Pb poisoned dogs. EDTA administration did not prevent the decrease in the albumin/globulin ratio. Clinical and prophylactic use of EDTA in Pb exposed workers gave the following results: (1) iv therapy did not increase Pb in the blood; urinary Pb was at the highest level 3 hr after administration; (2) oral therapy was ineffective; (3) oral prophylaxis for >6 mo decreased blood and urinary Pb and prevented anemia and other symptoms.]

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