103.

Gehres RF, Raymond S. A new chemical approach to the solution of urinary calculi. J Urol. 1951; 65:474-483. (CA47:8241c) [Calsol (Na salt of ethylenediaminetetraacetic acid) (I), in vitro, has optimal dissolving effect (Ca bound in H2O-sol. form) on urinary calculi in solns. of 1-3% and pH 7-8. The optimum concn. for clinical use appeared to be 1.5% (isotonic). Comparison with acid citrate G soln. showed that of stones obtained from 46 patients, 17 were attacked by soln. G, 35 by 1% I, and 43 by 3% I. In vivo, normal rabbit bladders exposed to the I solns. for 5-6 hrs. showed little or no toxic effects. Such solns. administered orally to rats or mice were well tolerated. I was recovered from the feces but not from the urine. Local irrigation is the only feasible method of application. In vivo irrigation rapidly dissolved 4 out of 6 artificially implanted urate calculi from rabbit bladders. I treatment was effective in 4 out of 7 patients with urinary calculi in a preliminary clinical trial.]

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