99.

Cann HM, Verhulst HL. Edathamil calcium-sodium (EDTA) in lead poisoning. Tennessee Ind. Hygiene News 15. 1958; 1:3-4. (2936) [Oral administration of EDTA in Pb poisoning in children cannot be considered a substitute for prevention of exposure to Pb. EDTA acts as a clinical "deleading" agent; but the process of "deleading" does not seem to be the only factor involved in the treatment of Pb poisoning. EDTA has not significantly reduced mortality from Pb poisoning. Compared to BAL, it seems to be more effective in reducing the incidence of residual neurological damage, but it is no more effective than BAL in terminating the acute episode of Pb encephalopathy. EDTA blocks Pb that is continually released by tissues into the extracellular fluids. A period of 48-72 hr of EDTA administration is necessary to reduce lethal concentration of Pb in the body to less toxic levels. The drug may be given by continuous iv route of a 2% solution or by intermittent intramuscular (im) injection in a total dosage range of 50-75 mg/kg body weight/24 hr for 5-7 days. Oral administration of EDTA is not as satisfactory as parenteral administration and may be harmful. Im instead of iv administration of EDTA helps in minimizing fluid intake.]

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