92.

Bell RF, Gilliland JC, Boland JR, Sullivan BR. Effect of oral edathamil calcium-disodium on urinary and fecal lead excretion. Comparative excretory studies with intravenous therapy. AMA Arch Ind Health. 1956; 13:366-371 (Apr.). (1642) [It is concluded from this study of the fecal and urinary Pb excretions of e Pb-poisoning cases treated daily with 3 g of CaNa2EDTA orally or iv, that: (1) Oral administration given while men are out of exposure cause a significant increase in both the fecal and the urinary Pb excretion. There is a 2-1/2-3-fold increase in the combined urinary and fecal Pb excretion with oral administration. 92) In these cases the combined fecal and urinary Pb-excretion response is approximately 2/3 as much on oral as on iv therapy. (3) There is a marked shift to urinary Pb excretion with both oral and in iv therapy. This shift is much greater with iv therapy. (4) Data on these cases suggest that fecal Pb excretion is diminished during iv therapy, but uncontrolled environmental factor may be the cause of this observation.]

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