84.

Peters HA, Eichman PL, Price JM, Kozelka FL, Reese HH. Abnormal copper and trytophan metabolism and chelation therapy in anticonvulsant drug intolerance. Diseases Nervous System. 1966; 27(2):97-107. (CA64:16509c) In 17 epileptics reacting adversely to Na diphenylhydantoin (200-800 mg. daily), urinary Cu excretion increased to 0.128 mg./l. as compared with a normal value of 0.03 mg./l. and a value of 0.05 mg./l. in epileptics with no adverse effects from the anticonvulsant. After the ingestion of a 2-g. load of L-tryptophan by 3 of the epileptics, abnormally large amts. of acetylkynurenine, kynurenine, and 3-hydroxykynurenine were excreted in the urine; this indicated an abnormal metabolism of L-tryptophan. When 7 of the patients who reacted adversely to Na diphenylhydantoin also received oral di-N Ca EDTA (0.5 g. daily) or dimercaptopropanol (100 mg. intramuscularly, 3 times daily), the adverse toxic effects of the drug were eliminated and more effective seizure control was observed.

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