83.

Parigi A, Rasetti L. Action of orally administered CaEDTA on the metabolism of the porphyrinic precursors in lead poisoning. Lavoro e Medicina 16. 1962; 3:44-50. (2452) Urinary excretion of porphobilinogen, d-aminolevulinic acid (ALA), coproporphyrin and Pb, and free erythrocytic protoporphyrin and Pb in the blood were measured in 8 Pb-polishers weekly for 2 wk. During the 3rd wk, each man was given an oral dose of 2 g CaNaEDTA daily for 6 days, while tests were continued during this and the following 4 wk. Administration of CaNa2EDTA produced a modest and not significant reduction of urinary porphobilinogen (av during wk 1, 2, 3 and 4, respectively, 8.02, 6.75, 5.18, and 4.7 mM/24 hr), but a marked reduction of ALA (121, 143, 93, 106 mM/24 hr). Erythrocytic protoporphyrin fluctuated (181, 322, 259, 218 mg/100 cc of red blood cells) whereas urinary coproporphyrin decreased by 50% (862, 1762, 625, 703 mg%/24 hr). Blood Pb showed slight insignificant variations (78, 92, 66, 71 mg/100 cc) but urinary Pb excretion increased considerably (248, 503, 718, 563 mg%/24 hr). Based on their findings of a rapid reduction of the precursors of porphyrin the authors assume a direct action of EDTA on the metabolism of porphyrin. The effect of orally administered EDTA seems to vary somewhat because no reduction of the porphyrin precursors was found in 2 cases with high Pb absorption. Possibly, the dose of administered CaNa2EDTA had been insufficient or the drug had been insufficiently absorbed.

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