77.

Stancev S. Prophylaxis of chronic lead poisoning by oral administration of CaNa2EDTA. First National Congress of Industrial Health. Abstracts of papers. 1963; 37-38. (2634) [A group of 14 workers was treated prophylactically for 8 days, without interruption of work, with 2 g CaNa2 (10 cc of a 10% solution in the morning and evening). These men, who were engaged in the production of Pb oxides, were exposed to elevated atmospheric concentrations of Pb and showed signs of incipient Pb poisoning. The Pb level in blood and urine was determined daily before and after treatment and compared with that of 10 untreated workers. The treated men excreted in their urine during the 8 days of treatment an amount of Pb which, without treatment, would have been excreted in the course of 52.3 days. Hematologic values and porphyrinuria improved. In 3 cases, urinary Pb excretion after administration of 1 g EDTA was determined every 2 hr for 24 hr. In other cases, serum Fe was determined and proved to be normal. In 2 cases, the prophylactic treatment was repeated with good success after 4 mo.
Oral treatment with 2 g EDTA in a 10% solution for 8 days is recommended for workers who show signs of incipient Pb intoxication and for those subjected to the inhalation of Pb. Prophylactic treatment with EDTA is much more efficient than that with Na citrate.

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