76.

Teisinger J, Zumanova R, Zezula I. Effect of calcium salt of ethylenediaminetetraacetic acid on the binding of lead by erythrocytes and blood proteins. Pracovni lekufstvi. 1957; 9:277-280. (CA52:9447g) Treating in vitro human erythrocytes (I) contg. bound Pb by various concns. of the title compd. (II) lowers the content of Pb in I by 35-80%, while Pb passes over into the compd. with II. Similar results are obtained with blood proteins. Reaction mechanism of the Pb exchange is discussed. Resorption of the calcium salt of ethylenediaminetetraacetic acid administered per os. J. Srbova and J. Teisinger. Ibid. Humans that had received 3 g. II in divided doses excrete in the urine on the av. 2.6% of the applied amt. of II. Although the oral administration of II results in a very low blood level of II, this method is very effective in removing Pb, however, only in short-term treatment of lighter cases of Pb poisoning.

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