72.

Berti T. Pharmacological investigation on sodium bismuth ethylenediaminetetraacetate (Bi-EDTA). Arch Ital. Sci. Farmacol. 1956; 6:293-298. (CA51:9939h) [Bi-EDTA was prepd. by reaction of Na2 ethylenediaminetetraacetate with an acid Bi nitrate soln., neutralization and crystn. Bi-EDTA was a cryst., white, odorless and tasteless powder, sol. 1:10 in H2O at 20°, insol. in org. solvents and fats. Treating by alkalis or H2S pptd. an oxide and a sulfide, resp.; pH of 2% soln., 6.7. The L.D.50 for rats, intramuscularly, subcutaneously, and orally was 0.1, 0.45, and 5 g./kg.; for rabbits, 0.09(intravenously), 0.38, and 4.5 resp. By mouth, the Bi-EDTA absorption was small (expts. also in humans), but enough for realizing an efficient Bi treatment. A comparison with other Bi compds., which may be administered by mouth, was made.]

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