68.

Saita G, Moreo L. Lead and porphyrins in the bile of patients with lead poisoning treated with calcium versenate. Med del Lavoro. 1958; 49:376-384 (May). (1956) [Fourteen cases of saturnism were studied for Pb content in urine, bile and feces during treatment with CEDTA given for 3-4 days at a dose of 2 g daily by iv or oral administration. The Pb content in the bile followed the usual pattern, ie, a rapid increase. The increase was lower in bile than in the urine, when compared to initial values: in the bile the increase was 1.3-6.3 times the values obtained before treatment (in the urine up to 75 times). In the bile Pb values >2 mg/l were seldom found; larger amounts were found in urine in most cases. Fecal excretion was also increased; the increase was similar to that observed in the bile. The average increase of Pb content in the bile and feces was almost the same for iv and oral administration of the drug. Urinary Pb was much higher after iv administration. Coproporphyrins in the bile decreased after EDTA treatment, the same as in urine. Bile excretion of protoporphyrin IX was scarcely influenced.

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