67.

Rotta C, Parigi A. Prevention of lead intoxication by oral administration of calcium versenate. Med del Lavoro. 1961; 52:769-779 (Dec.). (2325) [The prophylactic effect of CaNa2EDTA was studied in 280 Pb filers who were exposed to inhalation and ingestion of Pb particles. The drug was administered orally in daily doses of 2.5 g for alternate weeks over a period of up to 15 mo. Periodic check-ups during treatment did not disclose any significant side effects. The beneficial prophylactic effect of EDTA was demonstrated by comparing 2 groups of subjects, exposed to the same occupational environment, one group being treated and the other untreated. Some subjects, ~3-4%, in spite of treatment began to develop signs of a considerable Pb absorption. In these cases the elimination of Pb and the disappearance of the symptoms were achieved only by iv administration of CaNa2EDTA.

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