59.

Tripod J. General pharmacodynamic aspects of mobilizing iron with chelators. Atti Acad Med Lombarda, Suppl 20. 1965; 2025-2027. (CA67) [After the oral or s.c. administration of deferrioxamine (I) to a healthy dog, there is an increased elimination of urinary Fe which continues 1-2 days after the end of the treatment. In the rabbit, if the animal is overloaded with Fe, the effect of I is more apparent. The urinary excretion of a series of metals was measured in rabbits that received 2 s.c. 50 mg./kg. doses of I or EDTA. Compared with the controls, both substances increase the urinary excretion of Fe, but EDTA also influences the excretion of Mn somewhat and that of Zn considerably. The excretion of Cu and Ni is practically nil in the rabbit, and I and EDTA do not increase the elimination of these 2 metals. As protection against intoxication with oral FeSO4, a very satisfactory and longer protection is obtained if I is administered s.c. Orally and s.c., I does not protect against lethal doses of Cu, Mn, Ni, and Zn. S.c. EDTA protects against lethal doses of Fe, Ni, and Zn. Oral EDTA gives a much greater protection against Ni.

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