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Swenerton H, Hurley L S (Dept. Nutr. Univ. Calif., Davis, Calif.). Teratogenic effects of a chelating agent and their prevention by zinc. Science. 1971; 173 (3991), 62-64 (Eng). (CA75) [Ingestion of the chelating agent EDTA (I) (HO2CCH2)2NCH2CH2N(CH2CO2H)2 by female rats during pregnancy impaired reproduction and resulted in congenital malformations. When I (3%) was fed from days 6-21 of gestation, all of the full-term young had gross congenital malformations. These effects were prevented by simultaneous dietary supplementation with zinc (1000 ppm).]
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