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Desoille H, Albahary C, Truhaut R, Boudene C. The lead mobilization test using CaNa2EDTA. XII Intern Cong Occup Health. Helsinki, Finland. 1957; Vol. 111, Proceedings, pp. 287-290. (1773) [The EDTA mobilization test was applied in iv infusion (1 g/250 ml 5% glucose) or orally (4 g/24 hr) in Pb poisoning cases and in controls. Fourteen cases are described and the results of urinary, fecal, and blood Pb, as well as the course of azotemia are shown in tables. On the basis of the results, the authors conclude that usually a dose of 0.50-l g suffices for iv infusion. The following 8-hr urine must be examined. The 0.50 g dose can be injected directly without infusion, in 30 ml of the solvent. In this case the subject should empty his bladder before injection, and examination can be limited to the following 6-hr voidings. Except in acute, severe poisoning, there is no advantage in administering higher doses nor in performing >2 injections/wk. Such doses are not contraindicated for patients with nephritis, in fact may be of benefit if the ailment is due to Pb. Oral EDTA (4 g in 2 doses) is without danger, but does not produce Pb elimination of a magnitude obtained iv. So administered only 10-15% of the chelate penetrates the intestinal wall. PbEDTA there formed is more capable of passing into the circulation to be finally eliminated in the urine; this results in a slight decrease in fecal Pb, which could lead to error in interpretation. Persons never exposed to Pb eliminate 10 times the normal amount of Pb when EDTA is administered. A positive test of Pb mobilization is represented by urinary Pb of 500 mg/l when given orally, and 800-1000 mg/l when given iv. Since the principal route of industrial exposure to Pb is the respiratory, causing rapid absorption, the iv mobilization test will best reveal the degree of risk, especially for those excessively exposed for the 1st time.
Aside from this, the test is easily performed within the industry, and could perhaps be utilized prophylactically in workers who are insufficiently protected. However, these tests should in no way compete with technical control of occupations at risk of ….]

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