45.

Flanagan PR, Chamberlain MJ, Valberg LS. The relationship between iron and lead absorption in humans. Am J Clin Nutr. 1982; 36(5):823-9. (CA) [Approx. 60% of an oral dose of 100 mg of 203Pb was retained in 85 fasting subjects with no difference noted between males and females. Body retention was proportional to £400 mg of Pb. It was not related to the capacity to absorb Fe or to the size of body Fe stores, nor was it affected by the simultaneous ingestion of a 10-fold molar excess of Fe. The effect of several dietary factors was also detd. Pb retention was lowered by eating food, slightly increased by ingestion of fat, but was unaffected by the administration of lactose or a 10-fold molar excess of Zn, Co, or Ca. Ascorbic acid (I) slightly lowered the Pb retention, whereas EDTA produced a marked redn. Thus, human gastrointestinal Pb absorption behaves differently to that of rodents. In particular, human Pb retention was unrelated to Fe absorption or to body Fe stores.]

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