44.
Cohn SH. The effect of chemical agents on the skeletal content and excretion of internally deposited fission products. US Atomic Energy Comm. ANL-5584. 1956; 144-149. (CA51:4557f) [During a control period of 5 days, 24-hr. urine samples were collected daily for radioanalysis in order to establish a basal excretion rate. During the next 3 days the Ca salt of ethylenediamine-tetraacetic acid (EDTA) was administered orally daily, 1 g./25 lb. body wt. Twenty-four hr. urine samples were collected daily during the treatment period and for 5 days following treatment. No side effects from the use of this EDTA salt were observed. Blood counts and blood pressure remained unchanged throughout the treatment. The mean radioactivity in the urine following EDTA treatment was about 2.5 times the pretreatment activity. Thus, the oral administration of EDTA for a period of 3 days beginning 52 days post detonation slightly increased the excretion rate of internally deposited fission products. The over-all effect on decreasing the body burden in this situation, however, was insignificant as the excretion rate was very low at this time.]
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