41.

Calabrese A, Astolfi E, Mariani F. Oral treatment of lead intoxication with calcium versenate. Clinical and experimental study. Dia Medico. 1961; 33:2292-2294 (Oct. 5). (2239) [Three groups of rabbits were poisoned with 1 mg Pb acetate/day, group 1 by iv injection, groups 2 and 3 by gastric tube. In addition, groups 1 and 3 were given 100 mg CaEDTA, orally and by gastric tube, respectively. After 15 days all animals showed signs of Pb poisoning. Death occurred in the order of groups 3, 2, 1.
Twenty-three workers suffering from Pb intoxication as diagnosed by Burton's line, porphyrinuria, anemia and the presence of stippled cells and Pb in the blood, were given orally for 1 mo 200 mg CaEDTA/day. Improvement was noted in most cases after 15 days. In a serious case of a 37-yr old woman poisoned by litharge, oral and iv treatment were alternated.
The authors conclude that orally administered EDTA is useful as a detoxicant in cases that are not severe or as a continuation of iv treatment. However, oral treatment is contraindicated when the patient, concomitantly, is exposed to ingestion of Pb. Orally administered EDTA is not metabolized; it is eliminated in the urine by 34% in 48 hr and by 98% in 96 hr. Doses up to 98 g within 22 days do not cause untoward effects. The classic treatment consists of 5 g/day for 5 days and the same regimen repeated after 5 days rest.]

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