40.

Capellaro F, Galdo PC, Alliod R. Possibility of treating saturnism by versenate by the oral route. Minerva Medica. 1963; 54:474-477. (2508) [A group of 28 workers (18-58 yr old), of whom 12 showed initial signs of Pb absorption, 8 wee in the acute phase (colic), and 8 exhibited irreversible signs of poisoning (especially kidney and nervous system disorders) gave the following laboratory findings (means) before oral treatment with 1 g CaEDTA/day: Pb content in blood of 40-130 mg%, urinary Pb of 75-570 mg%, red cell protoporphyrin of 71-699 mg%, and coproporphyrinuria of 67-2515 mg/24 hr. Urinary Pb increased in the 1st group from 144.9 to 566.2 mg%, reaching its maximum in 2 days, and then fell to 131.6 mg% in 6 days. In more serious cases where Pb colic was present the same treatment caused a rise of urinary Pb from 410 mg% to 1172.5 mg% in 1 day and a drop to 352.6 mg% in 6 days. In the chronic cases, the rise of urinary Pb was from 99.3 to 323.7 mg% in 1 day, followed by a drop to 127.5 mg% in 6 days.]

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