38.

Foreman H. The pharmacology of some useful chelating agents. Metal Binding Med, Proc Symposium, Philadephia 1959. 1960; 82:94. (CA54:17719e) [A study of absorption, distribution and excretion of ethylenediaminetetraacetic acid (I) and diethylenetriaminepentaacetic acid (II) in the rat, by means of uniform C14 label in a positions of acetate groups. When given parenterally, less than 2.5% remained in body at 6 hrs. A small residue was slowly lost (likely resulting from chelation of iron strongly fixed in body). Oral I was poorly absorbed from gastrointestinal tract; fasting animals exhibited greatest absorption. No organ concentrated I to any extent (CaNa2 salt). There was a rapid disappearance from blood; turnover time of 57 minutes after intravenous administration. Vol. of distribution was slightly larger than extracellular space. I slowly traversed blood-spinal fluid membranes. Kidney was the only route of elimination of I from blood; active secretion of I by tubules as well as glomerular filtration occurred. The above studies were essentially duplicated in man. I caused hydropic degeneration of kidney proximal tubules, which was reversed when the drug was discontinued. Behavior of II was similar to I, with minor quant. differences. A whole-body counter was used to det. kinetics of metal removal by means of I and II. Affinities of I and II for various metals were given.]

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