36.

Davidsson L, Kastenmayer P, Hurrell RF. Sodium iron EDTA (NaFe(III)EDTA) as a food fortification: the effect on the absorption and retention of zinc and calcium in women. Amer J Clin Nutr. 1994; 60(2):231-237. (NA64) [The iron fortificant NaFeEDTA could have a potential negative effect on the metabolism of other minerals. Stable isotopes were used to monitor zinc and calcium metabolism in 10 women consuming a single meal of high-extraction wheat rolls (100 g flour) fortified with Fe 5 mg as FeSO4 or NaFeEDTA. 6-day chemical balances were made simultaneously to study apparent Zn and Ca retention from the complete diet containing the differently Fe-fortified breads (200 g flour; Fe 10 mg added daily). Mean 70Zn absorption from the bread meal increased from 20.9% with FeSO4 to 33.5% with NaFeEDTA whereas mean 44Ca absorption was 53.3% from both breads. When NaFeEDTA-fortified bread was consumed, there was a small but significant increase in urinary excretion of 70Zn and 44Ca. There was a similar small increase in urinary excretion during the 6-day balance, although the apparent retention of Zn and Ca was not different. Thus, no negative overall effect of NaFeEDTA consumption on the metabolism of Zn and Ca was found. In contrast, the results suggest that NaFeEDTA added to low-availability diets might increase Zn absorption a well as provide Fe with high availability.]

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