31.

Sidbury JB Jr., Bynum JC, Fetz LL. (US Public Health Serv.) Effect of chelating agent on urinary lead excretion. Comparison of oral and intravenous administration. Proceedings of Soc Experimental Biol and Med. 1953; 82:226-228. (1444) [Seven patients (5 adults and 2 children) with either symptoms of Pb poisoning or excessive amounts of Pb in their blood and/or urine, were treated with CaNa2EDTA. To the adults, 1 g was administered iv on the 1st day and 2.0 g/day thereafter for a total of 5 days. Children were given a test dose of 1/10 the calculated daily dose, and subsequently 30 mg/kg in 5% glucose in water twice daily. Orally, the dose for both adults and children was 30 mg/kg twice/day. In all cases, marked increases in urinary Pb were obtained. The iv administration was the more effective. Preliminary results indicated that EDTA is the most effective agent proposed for the treatment of Pb poisoning. Side reactions were minimal with the dosage schedule employed.

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