28.

Nakaue HS, Thomas JM, Reid BL. Comparison of EDTA, terephthalic acid, sodium sulfate and acetyl-salicylic acid as antibiotic potentiating agents in broiler chicks. Poultry Sci. 1967; 46:417-421. (NA38) [There were 3 experiments, each lasting 4 weeks, with 192 New HampshireXDelaware and VantressXArbor Acres chickens in electrically heated battery brooders from hatching. In the first two, 6 diets were each given to 32 chickens. On diet had no antibiotic and the rest had chlortetracycline 220 or oxytetracycline 550 mg pr kg, each with 0.4% ethylenediamine tetra-acetic acid (EDTA), acetylsalicylic acid, terephthalic acid or sodium sulphate. In the third experiment there were 12 diets each given to 16 chickens. Experimental diets had 550 mg chlortetracycline per kg and supplements were 0.1, 0.2, 0.3 or 0.4% acetylsalicylic acid or 0.4 or 0.8% EDTA, terephthalic acid or sodium sulphate. In the first experiment there was no significant difference in growth rate. Efficiency of feed conversion was best on the diet with 0.4% terephthalic acid and worst on that with 0.4% acetylsalicylic acid. In the second experiment 0.4% acetylsalicylic acid significantly depressed growth rate and efficiency was best with 0.4% EDTA and worst with 0.4% acetylsalicylic acid. Antibiotic in plasma was most on the diet with terephthalic acid. In the third experiment growth was significantly depressed by 0.3 or 0.4% acetylsalicylic acid and by 0.8% EDTA. Acetylsalicylic acid reduced and 0.8% EDTA or 0.4% terephthalic acid increased antibiotic in plasma.
(In the table and text discussing results the antibiotic is described as 220 mg oxytetracycline in the first experiment and 550 mg chlortetracycline in the second.)

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