22.

Pettinati L, Gribaudo C, Rasetti L. Oral and intravenous versenate in the therapy of chronic lesions caused by lead. Minerva Medica. 1962; 53:2092-2097 (July). (2458) [Five patients, suffering from cardiovascular, nervous, or renal lesions caused by chronic Pb intoxication, were given orally 2.5 g EDTA/day for 4 days, followed by a single iv dose of 1.5 g EDTA. Pb excretion in urine reached levels 3 times as high as those determined before oral treatment and then dropped on the 2nd day. Following the iv injection of EDTA Pb levels were 5 times as high as those before treatment. The findings indicated that EDTA is a useful therapeutic agent in treatment of chronic Pb intoxication, and that the iv route is more effective. No unfavorable reaction was observed under either form of EDTA administration. Although the degree of effectiveness of EDTA therapy is conditioned by renal function, this therapy is recommended even in cases of serious renal impairment.

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