21.

Pott R. Is prophylaxis of lead poisoning with EDTA possible? Archiv fur Gewerbe-pathologie Gewerbehygiene. 1959; 17:4:354-364. (2053) [A statistical study is presented covering 95 workers of a Cu-Pb mine who showed definite signs of Pb poisoning (20 stippled cells/50 fields, strong porphyrinuria, starting anemia) and were treated orally with 3 g EDTA/day for 4 wk while remaining on the job. Urinary Pb concentrations on the 6th and 20th day of treatment in ranges from <400->4000 mg/l are tabulated. The treatment appeared to be successful in 66 of the workers tested. However, the following sequelae raised doubts about the effectiveness of EDTA as prophylactic in Pb poisoning: (1) Signs of Pb intoxication reoccurred in 29 out of these 66 subjects within 2-3 mo after treatment; (2) 14 out of the 66 men had to be temporarily removed from Pb exposure within 3 mo and 2 others were given a 2nd treatment; (3) 38 developed gastric complaints within 7 mo.
Differences between iv and oral administration of EDTA are reviewed and presented in a diagram. A continuous oral treatment with daily doses of 0.5-1.0 g EDTA during the period of Pb exposure is proposed and experiments in this direction are suggested.

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