16.

Salvini M (Univ. Padua). The calcium chelate of disodium ethylenediamine tetraacetate in the treatment of saturnism. Folia Medica (Naples). 1955; 38:2:111-126. (1616) [Six volunteers were treated iv with a daily dose of 1 g CaNa2EDTA in 10% aqueous solution for 7 days; of the 9 workers exposed to Pb and hospitalized because of suspected poisoning, although they showed no clinical signs, 5 received the EDTA orally at 4g/day, and 4 received the same dose for 4 days and then were treated iv the same as the volunteers. No untoward manifestations other than diuresis were noted during the treatment and an observation period of 1 mo. In the subjects exposed to Pb, urinary Pb excretion increased while the excretion of coproporphyrins and the number of stippled erythrocytes decreased until normal values were reached when EDTA was administered iv, increased urinary Pb excretion became evident during the first 24 hr and reached a maximum on the 1st-2nd day. In oral treatment with EDTA the maximum Pb excretion was reached on the 3rd-5th day. The initiation of iv treatment after 4 days of oral administration showed that the 16 g of EDTA did not produce the displacement of chelatable Pb in the organism of such magnitude as would have diminished the effectiveness of 1 or 2 g EDTA iv. From this, the author concludes that present knowledge indicates that iv administration of the drug is preferable; also, that the slow and controlled infusion of isotonic dextrose solution is not compulsory, because the direction injection iv of hypertonic solutions was devoid of side effects.]

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